Abstract: Objective To summarize the clinical effects and nursing methods of TR-350 immunoadsorption in treatment of the national rare disease, the neuromyelitis optica spectrum disorders. Methods General
situation of the patients, abnormal reactions during treatment, equipment alarm, management and clinical results were collected. Results Visual acuity and nerve function improved significantly after the immunoadsorption treatment. The extended disability status scale (EDSS) reduced from (5.84 ± 2.16) to (4.46 ± 2.13)
(t=5.404, P=0.005). The concentration of anti- aquaporin- 4 autoantibody also decreased significantly from
(72.14±24.21)μ/ml to (16.72±6.63)μ/ml (t =10.793, P＜0.001). In the 68 cases during treatment, hypotension
occurred in one case, catarrh symptoms in 5 cases, equipment alarm in 14 cases, and unplanned termination of
the treatment in one case. Conclusions The immunoadsorption effect is obvious but the operation is complicated. Therefore, the operation nurses are required to strictly follow the operation processes, and have the abilities to analyze the cause of equipment alarm and to manage the emergencies to ensure success of the treatment.

Key words: Department of Nephrology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China , 2Department of Nephrology, China Rehabilitation Research Center, Beijing 100068, China