Chinese Journal of Blood Purification

Chinese Journal of Blood Purification ›› 2022, Vol. 21 ›› Issue (10): 754-757.doi: 10.3969/j.issn.1671-4091.2022.10.011

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Research progress in the effects of indoxyl sulfate on chronic kidney disease and its complications   

YANG Jing-yu,  FANG Jing-ai,  ZHANG Xiao-dong,  LIU Wen-yuan,  ZHANG Zi-yuan,  HU Ya-ling   

  1. The First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China; 2Department of Nephrology, Shanxi Medical University First Hospital, Taiyuan 030001, China
  • Received:2022-04-07 Revised:2022-06-29 Online:2022-10-12 Published:2022-10-12
  • Contact: 030001 太原，2山西医科大学第一医院肾内科 E-mail:fja3455001@126.com

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Abstract: Indoxyl sulfate (IS) is a uremic toxin of intestinal origin. Recent studies have shown that the accumulation of IS in the body will not only lead to the progression of chronic kidney disease (CKD), but also participate in the progression of cardiovascular disease, sarcopenia, cognitive impairment, osteopathy and anemia in CKD patients, thus reducing the quality of life and survival rate of CKD patients. This paper reviews the studies relating to the effects of IS on CKD and its complications in recent years, in order to provide new ideas for the prevention and intervention of CKD.

Key words: ndoxyl sulfate, Chronic kidney disease, Clinical outcome, Blood purification

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