Abstract: bjective To investigate the relationship between serum irisin level and lumbar bone mineral density (BMD) in maintenance hemodialysis (MHD) patients.  Methods A total of 200 MHD patients hospitalized in The First People's Hospital of Lianyungang City from Jan 2019 to Dec 2021 were recruited as the subjects for cross-sectional study. Based on the T value of lumbar bone, patients were divided into normal bone mass group (t ≥-1, n=119), osteopenia group (-2.5＜t＜-1, n=53) and osteoporosis group (t ≤-2.5, n=28). Clinical data and laboratory indexes were compared among the three groups. Pearson or Spearman correlation was used to analyze the correlation between lumbar BMD (expressed as T value) and clinical and laboratory indicators. The influencing factors for lumbar BMD were analyzed by ordered logistic regression.  Results  The serum irisin levels were 4.88±1.03μg/L, 35.05±8.94μg/L and 62.15±18.44μg/L in osteoporosis group, osteopenia group and normal bone mass group respectively (F=14.036, P＜0.001). Lumbar BMD in MHD patients was positively correlated with body mass index (BMI), creatinine and serum irisin (r=0.329, 0.295 and 0.448 respectively; P=0.001, 0.005 and ＜0.001 respectively), and negatively correlated with female, age, urea clearance index (Kt/V), urea clearance rate and alkaline phosphatase (r=-0.422, -0.291, -0.266, -0.270 and -0.292 respectively; P＜0.001, P=0.007, 0.017, 0.014 and 0.007 respectively). Ordered logistic regression showed that serum irisin level was an influencing factor for lumbar BMD in MHD patients (OR=0.466, 95% CI:0.304～0.714, P＜0.001).  Conclusion There is a positive correlation between serum irisin level and lumbar BMD in MHD patients. Serum irisin level is an influencing factor for lumbar BMD in MHD patients.

Key words: Maintenance hemodialysis, Irisin, Lumbar, Bone mineral density, Osteoporosis