Abstract: Chronic kidney disease is one of the public health problems harmful to human beings. Anemia is a major complication in chronic kidney disease patients, mainly caused by the decreased ability of erythropoietin (EPO) production in kidneys. Substances inhibiting erythropoietin production, iron deficiency, imbalance of iron homeostasis, chronic inflammation and short erythrocyte life span are the additional factors for anemia. Blood loss during hemodialysis is also involved in the anemia. Renal anemia may lead to cognitive impairment, increased hospitalization rate due to cardiovascular disease, and higher socio-economic burden, resulting in lower quality of life and higher mortality of the patients. High-flux dialysis is a blood purification method by using high-flux dialyzers instead of conventional dialyzers, having the advantage of efficient removal of medium and large molecular toxins to correct anemia. This paper summarizes the recent studies on the correction of anemia through dialysis, in order to clarify the mechanism of high-flux hemodialysis in the treatment of anemia.

Key words: High-flux hemodialysis, Renal anemia, Hepcidin-25, Inflammation