Chinese Journal of Blood Purification

Chinese Journal of Blood Purification ›› 2022, Vol. 21 ›› Issue (12): 878-882.doi: 10.3969/j.issn.1671-4091.2022.12.004

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Associations between bone mineral density and body composition in patients on maintenance hemodialysis

HU Xiao-hua, YU Hua, WU Bi-bo, HE Yun-lan, YU Yong，ZHANG Li-ming   

  1. Department of Nephrology, Shanghai Jing 'an District Zhabei Central Hospital, Shanghai 200070, China
  • Received:2022-07-05 Revised:2022-09-25 Online:2022-12-12 Published:2022-12-12
  • Contact: 200070 上海，上海市静安区闸北中心医院肾内科 E-mail:zlm198291@163.com

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Abstract: Objective  To investigate the relationship between bone mineral density and body composition in maintenance hemodialysis patients.  Methods  124 patients with stable conditions on regular dialysis in Shanghai Jing 'an District Zhabei Central Hospital at March 2021 were selected. General data such as age, sex, height, weight and body mass index (BMI), primary disease, and dialysis vintage was recorded for each patient. The body fat mass (BFM), Soft Lean Mass (SLM), Fat Free Mass (FFM), Skeletal Muscle Mass (SMM), Percent Body Fat (PBF) and Skeletal Muscle Index (SMI) were measured using a body composition analyzer. Bone density of the proximal radius was measured using a dual-energy X-ray absorptiometry. Calcium, phosphorus, and parathyroid hormone levels were also recorded. The bone mineral density (BMD) and related factors were statistically analyzed.  Results  BMD, SLM, FFM, SMM, and SMI were significantly higher in male patients (t=8.267, P＜0.001; Z=-7.492, P＜0.001; Z=-7.481, P＜0.001; Z=-7.495, P＜0.001;         t=6.560, P＜0.001), while PBF and dialysis age were lower than in female patients (Z=-4.555, P＜0.001;     Z=-2.444, P=0.015). The results of Spearman correlation analysis showed no correlation between BFM and BMD (r=0.121, P=0.181); SLM, FFM, SMM, BMI, and SMI were positively correlated with BMD (r=0.652, P＜0.001; r=0.648, P＜0.001; r=0.650, P＜0.001; r=0.294, P=0.001; r=0.632, P＜0.001), and PBF was negatively correlated with BMD (r=-0.209,P=0.020). The results of multiple linear regression analysis showed that dialysis vintage, gender, and SMI were important factors affecting BMD, and SMI was positively correlated with BMD among body composition (β=0.406, P＜0.001), while BFM, SLM, FFM, SMM, BMI, and PBF were not correlated with BMD (β=0.084, P=0.208; β=-0.178, P=0.400; β=-0.192, P=0.349; β=-0.133, P=0.518; β=0.081, P=0.339; β=0.089, P=0.214).  Conclusion  SMI in body composition has an important effect on bone mineral density in maintenance hemodialysis patients.

Key words: Hemodialysis, Bone mineral density, Body composition

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