Abstract: Objective  To explore the value of triglycerides-glucose (TyG) index in the evaluation of abdominal aortic calcification (AAC) in maintenance hemodialysis (MHD) patients.  Method  The MHD patients hospitalized in the Nephrology Department of the Second Affiliated Hospital of Anhui Medical University were enrolled in this study. Their clinical data and biochemical parameters were recruited and the AAC scores was evaluated by abdominal lateral X-ray film. Based on AAC score, the patients were divided into non-AAC group and AAC group. The correlation between AAC score and clinical parameters were analyzed to explore the value of TyG index in the evaluation of AAC.   Results  In the 130 MHD patients enrolled in this study, AAC was found in 67 patients (51.5%), in which 36.2% had moderate to severe AAC. Compared with non-AAC group, age (t= -3.642, P<0.001), dialysis age  (t= -2.458,  P=0.015), BMI (Z=3.776, P<0.001), neutrophil count (Z=2.041, P=0.041), total cholesterol (Z=2.364, P=0.018), triglyceride (Z=6.802, P<0.001), C-reative protein (Z=2.113, P=0.035) and TyG index (Z=7.247, P<0.001) were higher in AAC group. AAC score was positively correlated with age, BMI, total cholesterol, triglyceride, C-creative protein and TyG index (r=0.299, 0.274, 0.223, 0.640, 0.234 and 0.667 respectively;  P=0.001,  0.002,  0.013, <0.001,
0.014 and <0.001 respectively). Logistic regression analysis showed that age (OR=1.060, 95% CI : 1.001～1.122, P=0.046), dialysis age (OR=1.027, 95% CI:1.012～1.042, P<.001), BMI (OR=0.163, 95% CI: 11.016～1.331, P=0.028),  and TyG index (OR=133.874, 95% CI: 18.833 ～ 951.649,  P<0.001)  were the independent risk factors for AAC in MHD patients. The area under receiver operating characteristic (ROC) curve of TyG index for AAC was 0.871,with the cutoff point of 8.58, sensitivity of 80.0%,   and specificity of 84.1% (95% CI: 
0.812~0.931, P<0.001).   Conclusion  The incidence of AAC is high in MHD patients. TyG index is correlated with AAC, and has a better predictive value for AAC in MHD patients.

Key words: Maintenance hemodialysis, Triglycerides-glucose index, Abdominal aortic calcification; , Insulin resistance