Abstract: Objective  The current hemolysis test method is optimized to identify the dialyzers having adverse events.  Methods  The existed hemolysis test method was optimized from two aspects. On the one hand, the static contact time between the hollow fiber and the red blood cell suspension was increased from 60 min to 100 min, and on the other hand, the dynamic contact was added, i.e., the hollow fiber was slid 20 times in the red blood cell suspension after the static contact. Two dialyzers having adverse events and three other dialyzers were tested for hemolysis using the modified method.  Results  The hemolysis rate of the 2 dialyzers having adverse events was much higher than that of the other 3 dialyzers. The improved hemolysis test method can identify 2 dialyzers with adverse events.  Conclusion  The optimized hemolysis test method is useful to pick out the high-risk dialyzers.

Key words: Dialyzer, Hollow fiber, Hemolysis test, Dynamic contact