Abstract: Calprotectin (S100A8/A9) is a Ca2+ binding protein in the S100 protein family, having a wide range of biological activities and serving as a biomarker for many diseases. Peritoneal dialysis-related peritoneal fibrosis is one of the common complications in peritoneal dialysis (PD) patients. Many studies have recently proved that S100A8/A9 plays an important part in the development of peritoneal fibrosis. Our previous study also confirms that S100A8/A9 is up-regulated in peritoneal fibrosis and down-regulated after inhibition of peritoneal fibrosis. This article discusses the prospect of S100A8/A9 as a new target for the diagnosis and treatment of peritoneal fibrosis.

Key words: S100A8/A9, Peritoneal fibrosis, Peritoneal dialysis