Abstract: Objective  To investigate the effect of 5E rehabilitation model on micro-inflammatory state and quality of life among patients undergoing hemodialysis.  Methods  A total of 120 maintenance hemodialysis patients treated in the Blood Purification Center of Wuxi 9th Hospital Affiliated to Soochow University were selected and randomly divided into control group (n=60) and observation group (n=60). Patients in the control group were conducted conventional nursing, while the observation group conducted 5E rehabilitation model on the basis of conventional nursing. After 6 months of intervention, the level of hs-CRP、TNF-α、IL-6 and malnutrition inflammation score and 36-item short form health survey scores were compared between two groups.   Results  After 6 months of intervention, the levels of hs-CRP、TNF-α、IL-6 and malnutrition-inflammation scores in the observation group were lower than these in the control group respectively(t=2.300,4.959,2.649,2.298,P=0.023,＜0.001,0.009, 0.024). There was no significant difference in the score of SF-36 dimension item of mental health between the observation group and the control group(t=-1.877,P=0.063). Item scores of other dimensions in the observation group were higher than these in the control group (t=-2.527, -3.220,-2.963,0.002,-5.963,4.959,-4.177,P=0.013,0.002,0.004,0.001,＜0.001).  Conclusion  5E rehabilitation model may effectively improve the micro-inflammatory state, nutritional status and quality of life among MHD patients.

Key words: 5E rehabilitation model, Maintenance hemodialysis, Micro-inflammatory state, 36-item short form health survey, Clinical therapeutic effect