Abstract: Conventional glucose-based peritoneal dialysates with higher glucose concentrations, high glucose degradation products, advanced glycation end products and lower pH have been recognized as bio-incompatible, affecting peritoneal dialysis efficacy and leading to technique failure. pH-neutral, low-glucose degradation product dialysates are relatively biocompatible, and are thought to be superior to the conventional dialysates especially in long-term use of peritoneal dialysis. In this paper, we review the recent advances in pH-neutral, low-glucose degradation product dialysates on the residual renal function, peritoneal function, peritonitis rate, patient and technique survival, and peritoneum pathology in peritoneal dialysis patients.

Key words: Peritoneal dialysis, End stage renal disease, pH-neutral, low-glucose degradation product solution