Abstract: Enhancer of zeste homolog 2 (EZH2) is a histone lysine methyltransferase, which induces the silence of target gene by regulating trimethylation of Lys27 in histone 3 (H3K27me3) and plays an important role in peritoneal dialysis-associated peritoneal fibrosis. Studies have shown that EZH2 is highly expressed in the process of peritoneal fibrosis and induces the development of peritoneal fibrosis by promoting epithelial-to-mesenchymal transition (EMT), peritoneal inflammation and angiogenesis. Inhibition of EZH2 can reduce or even partially reverse peritoneal fibrosis. Further study of EZH2 can be helpful to clarify the pathogenesis of peritoneal fibrosis and to find out target treatment for peritoneal fibrosis.

Key words: Enhancer of zeste homolog 2, Peritoneal dialysis, Peritoneal fibrosis