Abstract: Objective   To investigate the effects of serum heme oxygenase-1 (HO-1), hypoxia inducible factor-1α (HIF-1α) and fibroblast growth factor 23 (FGF23) on vascular calcification in peritoneal dialysis (PD) patients.  Methods   A total of 109 PD patients admitted to The Central Hospital of Jiaozuo Coal Industry (Group) Co., Ltd. from May 2019 to May 2022 were selected. Lateral abdominal plain radiographs were used to detect vascular calcification in the PD patients. According to the presence or absence of abdominal aortic calcification, patients were divided into the calcification group and the non-calcification group. Clinical data and serum HO-1, HIF-1α and FGF23 were compared between the two groups. Logistic regression was used to analyze the influencing factors of abdominal aortic calcification in PD patients. The predictive values of serum HO-1, HIF-1α and FGF23 for abdominal aortic calcification were analyzed by ROC curve.  Results  Serum HO-1 was lower, and serum HIF-1α and FGF23 levels were higher in calcification group than in non-calcification group (t=5.762, 8.176, and 9.382 respectively; P＜0.001). Logistic regression showed that age (OR=1.359, 95% CI 1.048～1.763, P<0.001), serum phosphorus (OR=1.994, 95% CI 1.123～3.539, P＜0.001), HO-1 (OR=0.857, 95% CI 0.762～0.964, P＜0.001), HIF-1α (OR=2.211, 95% CI 1.156～4.228, P＜0.001) and FGF23 (OR=3.916, 95% CI 1.957～7.836, P＜0.001) were the factors affecting the presence of abdominal aortic calcification in PD patients. The AUC predicted by HO-1, HIF-1α, FGF23 and their combination were 0.789, 0.868, 0.902 and 0.972 respectively.  Conclusions   Serum HO-1, HIF-1α and FGF23 levels are the independent influencing factors for abdominal aortic calcification in PD patients. Anyone of the three levels has a predictive value, but their combined has a higher predictive value for the presence of abdominal aortic calcification.

Key words: Fibroblast growth factor 23; , Heme oxygenase-1; , Hypoxia inducible factor-1α; , Peritoneal dialysis; , Vascular calcification