Abstract: Objective To systematically summarise the factors influencing the occurrence of ischaemic stroke (IS) in maintenance haemodialysis (MHD) patients. Methods Relevant literature from CNKI, Wanfangdata, VIP, CBM, PubMed, EMbase, The Cochrane Library, and web of science databases were searched, all from the time of database creation to February 2023. Two investigators independently screened the literature, extracted information, and evaluated the literature for quality, and Meta-analysis was performed using RevMan 5.3 software. Results A total of 14 cohort studies with a sample size of 6,876 cases were included, and the quality of the literature was high. 14 studies identified a total of 6 risk factors and 1 protective factor, and the effect of history of IS and diabetic nephropathy on the development of IS in MHD patients was inconclusive. meta-analysis results showed that age (HR=1.04, 95% CI:1.03 to 1.06), diabetes (HR= 1.88, 95% CI:1.38 to 2.58), history of atrial fibrillation (HR=2.71, 95% CI:1.73 to 4.27), history of cerebrovascular disease (HR=4.97, 95% CI:3.16 to 7.82), NT-proBNP (HR=4.43, 95% CI:1.66 to 11.80), serum phosphate (HR= 0.57, 95%CI:0.44 to 0.74), and platelet count (HR=1.01, 95%CI:1.00 to 1.02) were influential factors in the development of IS in MHD patients. Conclusions Healthcare professionals can identify people at risk for IS in MHD patients based on these factors and intervene early to improve the quality of life of MHD patients.

Key words: Maintenance hemodialysis, Ischemic stroke, Risk factor, Cohort study