Abstract: Objective  To investigate the influencing factors of lung ultrasound B-line formation and its prognosis value in peritoneal dialysis (PD) patients.  Methods  A total of 200 PD patients regularly followed up in the Nephrology Department of Huzhou Central Hospital were selected and divided into mild group, moderate group and severe group according to the number of lung ultrasound B-lines. Their relevant data were collected, and they were follow-up for 19 (15, 24) months.  Results  Multivariate linear regression showed that the number of lung ultrasound B-lines was correlated with systolic blood pressure (β=0.090, P=0.003), diastolic blood pressure (β=0.201, P＜0.001), ultrafiltration volume (β=−0.010, P=0.017), hemoglobin (β=−0.112, P=0.026), blood brain natriuretic peptide (BNP; β=0.008, P＜0.001) and pulmonary artery systolic blood pressure (β=0.294, P=0.006). Multivariate Cox regression showed that the number of lung ultrasound B-lines (OR=1.109, 95% CI:1.019～1.208, P=0.017), cardiac functional grade (OR=4.290, 95% CI: 1.564～11.771, P=0.005) and BNP (OR=1.001, 95% CI: 1.000～1.002, P=0.003) were the independent risk factors for cardiovascular disease in PD patients. Kaplan-Meier survival analysis showed that the median survival periods could not be calculated in mild group (n=95), and were 29 and 21 months in moderate group (n=68) and severe group (n=37) respectively; the overall survival period was different among the three groups (χ2=16.384, P＜0.001).  Conclusion  The formation of lung B-line examined by ultrasonography is influenced by many factors in PD patients. The number of lung ultrasound B-lines is an independent risk factor for cardiovascular disease, and is also associated with the prognosis of PD patients.

Key words: Peritoneal dialysis, Lung ultrasound B-line, Influencing factors, Prognosis