Abstract: Objective  To investigate the relationship between frailty and body composition and nutritional status in maintenance peritoneal dialysis (PD) patients.  Methods   A cross-sectional survey of PD patients with regular follow-up in a single center was conducted. Clinical frailty scale was used to evaluate the physical function of the patients, and the Inbody720 (Biospace) bioelectrical impedance meter was used to determine the body composition of the patients. The demographic and clinical data of the patients were collected. The influencing factors for frailty in PD patients were analyzed.  Results  A total of 528 PD patients were included, of which 127 (24.1%) had frailty. Compared with the non-frailty group, frailty patients had higher body fat mass (t=4.148, P＜0.001), obesity degree (t=2.629, P=0.009), body mass index (t=2.389, P=0.017) and edema index (t=6.588, P＜0.001), and lower bone mineral mass (t= -2.417, P=0.016), skeletal muscle mass (t=-3.706, P＜0.001), intracellular fluid volume (t=-3.714, P＜0.001), total fluid volume (t=-2.947, P=0.003), lean body mass index (t=-2.245, P=0.025), serum total protein (t =-2.486, P=0.013), albumin (t=-6.329, P＜0.001) and prealbumin (t=-7.638, P＜0.001). Multivariate binary logistic regression analysis showed that older age (OR=1.130, 95% CI: 1.076～1.186, P＜0.001), higher Charlson comorbidities score (OR=1.599, 95% CI:1.206～2.119, P＜0.001), higher systolic blood pressure (OR=1.043, 95% CI:1.017～1.070, P＜0.001), lower diastolic blood pressure (OR=0.939, 95% CI: 0.898～0.981, P=0.005) and lower serum albumin (OR=0.858, 95% CI: 0.780～0.944,P=0.002) were the independent risk factor for frailty in PD patients.  Conclusions The incidence of frailty in PD patients was 24.1%. Lean body mass index, obesity degree and edema index were correlated with frailty. Nutritional status, older age, comorbidities and blood pressure were the independent influencing factors for frailty in PD patients.

Key words: Peritoneal dialysis, Frailty, Body composition, Nutritional status