Abstract: Objective  To establish for the first time a risk prediction model for complications related to femoral vein catheterization for blood purification in children, and to verify the prediction performance.  Methods  A total of 428 children with blood purification via femoral vein in the Pediatric Nephrology Department of West China Second University Hospital in Chengdu from January 2020 to June 2022 were selected. The risk factors for complications related to femoral vein catheterization were analyzed by univariate and multivariate logistic regression, and a risk prediction model presented as a nomogram was then developed. Receiver operating characteristic (ROC) curve and calibration curve were used to assess the discrimination and calibration of the model, and a total of 50 children with femoral vein blood purification and hospitalized in the same hospital from July 2022 to October 2022 were selected to verify the model.  Results  Multivariate regression analysis showed that etiology of renal failure, hypoalbuminemia, dysphoria, lower extremity edema, hypertension, peritoneal effusion, infusion of blood or blood products were the risk factors for femoral vein catheter-related complications in children with blood purification. The area under the ROC curve of the model was 0.794 (95% CI: 0.738～0.851, P<0.001), with the sensitivity of 0.733 and the specificity of 0.725. The maximum Youden index was 0.458, with prediction model’s goodness-of-fit of χ2=3.395 and P=0.907. Model verification results showed that the area under the ROC curve of the model was 0.810 (95% CI: 0.689～0.931, P<0.001) with the sensitivity of 0.739 and the specificity of 0.778.  Conclusion  This model has a satisfactory performance, and provides a reference for nurses to identify high-risk children and implement prevention care.

Key words: Children, Blood purification, Femoral vein catheter, Complication, Risk factor, Prediction model