Abstract: Objective  To investigate the predictive value of baseline systemic inflammatory response index (SIRI) for peritoneal dialysis-associated peritonitis (PDAP) in peritoneal dialysis (PD) patients.  Methods  A total of 140 patients undergoing PD catheterization in the Second Affiliated Hospital of Anhui Medical University from January 2014 to December 2020 were retrospectively analyzed. They were divided into peritonitis group and non-peritonitis group according to the presence or absence of PDAP. General clinical data and laboratory indexes were compared between the two groups. Binary logistic regression was used to analyze the risk factors for PDAP, and receiver operating characteristic (ROC) curve was used to evaluate the predictive value of baseline SIRI for the occurrence of PDAP. According to the prognosis in peritonitis group, the patients were further divided into a successful treatment group and an ineffective treatment group; the risk factors for peritonitis treatment failure were then analyzed.  Results  SIRI (Z=-4.347, P<0.001), white blood cell count (Z=-3.590, P<0.001), serum phosphorus (Z=-5.499, P<0.001), serum alkaline phosphatase (Z=-2.452, P=0.014), and total cholesterol (Z=-2.195, P=0.028) were significantly higher in the peritonitis group than in the non-peritonitis group. Multivariate logistic regression showed that higher SIRI (OR=2.084, 95% CI: 1.054～4.121, P=0.035), higher serum phosphorus (OR=11.826, 95% CI: 4.204～33.262, P<0.001) and higher serum alkaline phosphatase (OR=1.010, 95% CI: 1.002～1.019, P=0.022) were the risk factors for PDAP. ROC curve showed that the area under the curve of SIRI was 0.720, with the sensitivity of 69.2% and specificity of 67%. Higher baseline SIRI level (OR=0.446, 96% CI: 0.208～0.959, P=0.039) was a risk factor for treatment failure of PDAP.  Conclusions The baseline SIRI is associated with the risk of PDAP in PD patients, and is a good predictive indicator for the occurrence and prognosis of PDAP.

Key words: Systemic inflammatory response index, Peritoneal dialysis-associated peritonitis, Risk factor