Chinese Journal of Blood Purification

Chinese Journal of Blood Purification ›› 2024, Vol. 23 ›› Issue (02): 130-133.doi: 10.3969/j.issn.1671-4091.2024.02.011

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Research advances in the relationship between hypoxia-inducible factor-1α and renal fibrosis

YAN Tong, JIA Xin-yan, GUO Ming-hao   

  1. Department of Nephrology, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China
  • Received:2023-10-23 Revised:2023-11-28 Online:2024-02-12 Published:2024-02-12
  • Contact: 453100 卫辉,1新乡医学院第一附属医院肾内科 E-mail:13937315636@163.com

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Abstract: Renal fibrosis is the common pathological hallmark of various chronic kidney diseases, characterized by progressive accumulation of extracellular matrix (ECM). Hypoxia-inducible factor (HIF) is a key regulator of body’s response to hypoxia. HIF regulates ECM synthesis, epithelial-mesenchymal transition (EMT) and pro-fibrosis signaling pathways. This review summarized the relationship between HIF-1α and renal fibrosis.

Key words: Hypoxia, Hypoxia-inducible factor, Renal fibrosis, Epithelial-mesenchymal transition

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