Abstract: Objective  To systematically analyze the risk factors for abdominal aortic calcification (AAC) in Chinese maintenance hemodialysis (MHD) patients.   Methods  PubMed, EMBASE, Web of Science, CNKI, CBM, Wanfang and other databases were searched from establishment of the database to May 2023 by computer to retrieve the literature relating to the risk factors for AAC in Chinese MHD patients. The Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) were used to evaluate the methodological quality of the literature. Meta-analysis was performed using RevMan5.3 software.  Results  A total of 15 articles were obtained, including 10 Chinese articles and 5 English articles and encompassing 2,848 subjects. The results of Meta-analysis showed that older age (OR=1.080, 95% CI: 1.050～1.110, P<0.001), longer dialysis age (OR=1.020, 95% CI: 1.010～1.040, P=0.008), smoking (OR=1.900, 95% CI: 1.440～2.500, P<0.001), higher body mass index (BMI) (OR=1.200, 95% CI: 1.050～1.110, P=0.001), increased blood calcium (OR=14.140, 95% CI: 7.340～27.260, P<0.001), elevated blood phosphorus (OR=6.010, 95% CI: 2.040～17.750, P=0.001), elevated parathyroid hormone (OR=1.310,95% CI:1.010～1.700,P=0.040), elevated blood magnesium(OR=0.490, 95% CI:0.400～0.590, P<0.001) and decreased 25-hydroxyvitamin D3 (OR=0.760, 95% CI: 0.610～0.950, P=0.020) were the risk factors for AAC in MHD patients.  Conclusion  There are many influencing factors for AAC in MHD patients. We should focus on the high-risk groups and carry out targeted and personalized interventions to delay the progress of AAC in MHD patients.

Key words: Maintenance hemodialysis, Abdominal aortic calcification, Risk factor