Abstract: Rhabdomyolysis (RM) is a multifactorial clinical syndrome of skeletal muscle injury and release of its breakdown products into the circulation. Acute kidney injury (AKI) is a common complication of RM, which is mainly related to myoglobin occlusion of renal tubules and its direct nephrotoxic effects, and others. RM-induced AKI has a low cure rate and high mortality. Previous studies have shown that continuous renal replacement therapy (CRRT) combined with hemoperfusion (HP) can be effective in treating RM-induced AKI. This article provides a review of CRRT combined with HP in the treatment of RM-induced AKI with the aim to provide a reference for clinical therapeutic decision-making and possible follow-up studies.

Key words: Rhabdomyolysis, Acute kidney injury, Myoglobin；Continuous renal replacement therapy, Hemoperfusion