Abstract: Anticoagulation strategy ensures filter patency and delivery of an adequate continuous renal replacement therapy (CRRT) dose. Most guidelines recommend the regional citrate anticoagulation (RCA) as the first-line method for patients requiring CRRT. Previous use of the traditional regional citrate anticoagulation had several drawbacks such as complex operation, risks of acid-base imbalance and metabolic disorders, leading to the restriction of its clinical applications. By contrast, citrate-based replacement fluids solve these deficiencies. This article reviews the research progress in citrate-based replacement fluids from point of view of  anticoagulation effectiveness, treatment efficiency and security.

Key words: Continuous renal replacement therapy, Regional citrate anticoagulation, Citrate-based , replacement fluid