Abstract: Objective  To explore the relationship between serum liver kinase B1 (LKB1) level and vascular calcification in peritoneal dialysis (PD) patients.  Methods  A total of 78 patients (≥ 3 month) who were treated with PD in the Department of Nephrology of Qingdao Municipal Hospital from September 2022 to September 2023 were included in the study. Collect the clinical data and laboratory indicators of Finalists; ELISA was used to detect the serum LKB1 level; the degree of vascular calcification and the abdominal aortic calcification score (ACCs) was evaluated by abdominal lateral X-ray plain film. Spearman correlation analysis and multiple linear regression analysis of influencing factors of serum LKB1 level in patients with PD; the influencing factors for serum LKB1 level were evaluated by Spearman correlation analysis and multivariate linear regression, and the influencing factors for abdominal aortic calcification score (AAC) in PD patients were assessed by Logistic regression. Results  Serum LKB1 level was lower in the PD patients than in the healthy controls (Z=-4.393，P<0.001). LKB1 level was negatively correlated with age, dialysis age, PTH, triglyceride and AACs (r=-0.262，-0.227，-0.293，-0.259，-0.611; P=0.021，0.046，0.009，0.022，＜0.001). Multivariate linear regression showed that PTH and AACs were the independent influencing factors for serum LKB1 level (β=-0.208, -0.519; P=0.042，＜0.001). Logistic regression analysis demonstrated that high serum LKB1 level was an independent protective factor for AAC in PD patients (OR,95% CI：0.961 (0.936, 0.986), P=0.003). ROC-AUC of serum LKB1 for moderate to severe AAC was 0.812 (95% CI：0.719～0.905, P＜0.001), cut-off value 115.68ng/L, sensitivity 0.622, and specificity 0.854, the Yoden index is 0.476. Conclusions  Serum LKB1 level in PD patients is lower than that in healthy people, and was associated with the AAC.

Key words: Liver kinase B1, Peritoneal dialysis, Abdominal aortic calcification, Vascular calcification