Chinese Journal of Blood Purification

Chinese Journal of Blood Purification ›› 2025, Vol. 24 ›› Issue (09): 759-763.doi: 10.3969/j.issn.1671-4091.2025.09.008

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Research progress on the mechanism, prognostic value, diagnosis and treatment of worsing renal function in CRS-1

SONG Chao, LIN Qiong-zhen   

  1. Department of Nephrology，The First Hospital of Hebei Medical University，Shijiazhuang 050023，China
  • Received:2024-11-12 Revised:2025-06-09 Online:2025-09-12 Published:2025-09-12
  • Contact: 050023 石家庄，1河北医科大学第一医院肾内一科 E-mail:57203218@hebmu.edu.cn

Abstract: Cardiorenal syndrome type 1 (CRS-1) refers to the pathophysiological syndrome of acute kidney injury (AKI) caused by acute deterioration of cardiac function. It is more common in acute decompensated heart failure (ADHF). AKI in the development of CRS-1 is also known as worsening renal function (WRF). This article reviews the definition, diagnostic criteria, pathogenesis, clinical significance and etiology of WRF in CRS-1, as well as therapeutic strategies for WRF. The aim is to enhance recognition of AKI in CRS-1 and deepen understanding of its pathophysiology, thereby providing a theoretical basis for improving CRS-1 management and patient prognosis.

Key words: Cardiorenal syndrome type 1, Acute kidney injury, Acute decompensated heart failure, Worsening renal function

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