Gestational hyperlipidemia-induced severe acute pancreatitis (HLSAP) is a life-threatening complication. We report a 22-year-old pregnant woman (gestation of 29 weeks) with HLSAP with serum triglyceride (TG) of 78.65 mmol/L. Double filtration plasmapheresis (DFPP) was initiated within 24 hours. After two sessions, TG decreased to 21.65 mmol/L (72.5% reduction) with resolved abdominal pain within 24 hours. She was discharged on day 11 and delivered a healthy infant via cesarean section at 38 gestational weeks. Early DFPP effectively clears lipids and inflammatory mediators, ensuring maternal-fetal safety.