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Chinese Journal of Blood Purification ›› 2002, Vol. 1 ›› Issue (11) : 20-22.

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Abstract

【Abstract】Objective To observe the clinical effect of a new type of membrane plasma separator（Evacure-4）on severe hepatitis patients with liver failure. Methods 22 cases served as treatment group and 15 cases as control group. Both groups were given similar basic medical treatment and plasma exchange. During the process of plasma exchange, the treatment group was treated with a new type of membrane plasma separator（Evacure-4）which was made from ethylene-vinylalcohol , but the control group was treated with Ps-06 membrane plasma separator made from polyamide. Both groups were exchanged the same target plasma volume. Results 19 cases survived in the treatment group, and the total survival rate was 86.3%; However, in the control group, 8 cases survived and the total survival rate was 53.3%. The conscious rate of hepatic coma was 90% in the treatment group, however, in the control group was 83.3%. The new type of membrane plasma separator（Evacure-4）can effectively remove metabolite including bilirubin and so on（P<0.01）. To contrast with Ps-06, using Evacure-4 to carry out plasma exchange not only can reduce the loss of albumin, but can improve prothrombin time better. During the process of treatment, the side effect of rupture of red cells wasn't found. Conclusion It is available and safe using the new type of membrane plasma separator（Evacure-4）to treat patients with severe hepatitis.