Abstract
【Abstract】Objective The purpose of this study was to measure, in commercially available hemodialyzers, the spatial variation of the mass transfer area coefficient (KoA) for urea and to evaluate its dependence on dialysate flow rate (Qd) and blood flow rate (Qb).Methods Two different models of hollow fiber dialyzer were used in vitro for nine countercurrent Qb and Qd combinations. Results KoA for urea varied with dialyzer model, but the effect of Qb, Qd. Urea KoA did not change significantly when Qb increased from 300 to 500 ml/min at Qd of 500, 800 and 1000 ml/min. When Qd increased from 500 to 1000 ml /min at a Qb between 300 and 500 ml/min, however, urea KoA increased significantly. Conclusion These data demonstrate that increasing Qd alters the mass transfer characteristics of hollow fiber dialyzers and results in increased urea clearance.
Key words
Hemodialyzer /
Mass transfer area coefficient (KoA)
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