【Abstract】Objective To study the role of sympathetic nervous system expressed by plasma adrenaline and noradrenaline level in the hypertension of hemodialysis patients. Methods 12 hypertension hemodialysis patients were taken into the hypertension group, 6 male, 6 female, aged from 30 to 60 years old. Another 12 normotensive hemodialysis patients were as the control group. Each patient's blood sample was taken at pre and post hemodialysis procedure for plasma noradrenaline adrenaline level, meanwhile, mean arterial blood pressure (MAP) was measured. Results Post-dialysis MAP in comparison to pre-dialysis MAP was similar in hypertension hemodialysis patients. Plasma adrenaline and noradrenaline levels in hypertension group were higher than control group and were not different between pre and post dialysis. These levels were not correlated with MAP or body weight alterations. Conclusion It is suggested that sympathetic activity, as it was expressed by plasma catecholamine alterations, is associated with hemodialysis hypertension.