Abstract
【Abstract】Objective To detect serum concentrations of tumor necrotic factor(TNF-а), interleukin-1 (IL-1), interleukin-6 (IL-6) during continuous veno-venous hemofiltration therapy(CVVH) methodology. Methods Thirty patients treated with CVVH，AV600 hemofilter (Polysulfone,1.4m2) was used, Blood and ultrafiltration fluid was sampled before and 2, 6, 8 hours in the process of CVVH. Results During CVVH procedure, TNF-α, IL-1 and IL-6 levels were decreased progressively, got to the lowest at 6 hours,which was significantly lower than 0 hour。After 8 hours, TNF-α, IL-1 and IL-6 levels increase slowly, and none of the three mediators could be detected in the ultrafiltration fluid. Conclution Serum TNF-α, IL-1 and IL-6 got to the nadir at 6 hours in the process of CVVH with polysulfone hemofilter and the clearing of these mediators may be mainly through absorption but not filtration.
Key words
Cytokine
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