【Abstract】 Objective To explore the cause of changes in serum c-reactive protein(CRP) and inflammation in the malnutrition and anemia of uremic patients with hemodialysis(HD). Methods Detect 31patients with HD and 15 normal controls CRP、SCr、Alb、Hb、SF and CRP after HD, uremic patients with were divided into normal group (CRP<10mg/L), and abnormal group(CRP>10mg/L). Results Normal group with the abnormal group,Alb、Hb were significant difference was observed between groups(P<0.01), CRP increase significantly after HD compared with that before HD, CRP had significant difference in patients before and after HD(CRP<0.01).In patients of normal group and abnormal group,negative correlations of CRP with Alb、Hb were found.CRP was not found correlated with SCr and SF. Conclusions HD itself and individual is an important factor to increase CRP of serum patients with HD. Inflammation has an important role in the malnutrition and anemia of uremic patients with HD.