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Chinese Journal of Blood Purification ›› 2002, Vol. 1 ›› Issue (7) : 23-25.

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Abstract

【Abstract】objective To observe the effect of different dialyzers and the reused dialyzers (used 5 times) on the activation of platelet. Methods The three kinds of dialyzer membranes (cellulose acetate, hemophan, polysulfone) were randomly used on three groups of maintenanc hemodialysis(MHD) patients. The levels of serum P-selectin of each group of patients were measured with ELISA method at different time points (0min, 270min) during HD using new and reused dialyzer membranes. In addition, the levels of serum P-selectin were measured by ELISA in non-dialysis uremic patients and healthy control.Results Compared with the control group, the levels of P-selectin slightly increased in all uremic patients, and there were not significant difference between the dialysis and non-dialysis patients (P>0.05). During the course of dialysis, the levels of P-selectin increased rapidly after 15 minutes(compared with the pre-dialysis, P<0.05), and the levels of P-selectin continually increased following HD performed. At 270 minutes after dialysis, compared with the initial levels, it increased significantly (P<0.001). There were different effects of three kinds of first using dialysis membranes on the levels of P-selectin. It in patients with CA dialyzers were more than these with PS and HE dialyzers, and there were not significant difference in the levels of P-selectin among the three kinds of reused dialyzers, but there were significantly decreased compared with the first used dialyzers (P<0.05). Conclusion The significantly increasing levels of P-selectin are one of the many factors resulting in the dysfunction of hemostatsis and coagulation. The effect of HE and PS on the activation of platelet are less than that of CA.