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Chinese Journal of Blood Purification ›› 2002, Vol. 1 ›› Issue (9) : 26-28.

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Abstract

【Abstract】Objective To study the laboratory parameter of low molecular weight heprin (LMWH) and unfractionated heparin (UFH) in hemodialysis. Methods 22 patients with chronic renal failure were given LMWH and UFM anticoagulanition separately. Detection and comparison the AFXa. thrombin time (TT) and activated partial thromboplastin time (APTT) of these two kinds of anticoagulanition. Results The APTT and TT in LMWH group do not prolong significantly in hemodialysis, while they prolong significantly in UFH group at 30 minutes after hemodialysis and at the end of hemo diylsis. The value of AFXa in LMWH group has significant difference between before and in hemodialysis, and it is significantly higher in hemodialysis than UFH group. Conclusion LMWH anticoagulanition has no effect on APTT and TT,but it has the effect on AFXa. LMWH anticoagulanition has more effecacy and safety in hemodialysis than UFH.