PDF(2385 KB)

Chinese Journal of Blood Purification ›› 2003, Vol. 2 ›› Issue (1) : 11-13.

论著

Author information +

History +

Abstract

【Abstract】Objective To observe the levels of the ionized calcium（Ca2+）, total calcium（TCA）, parathyroid hormone（PTH）and bone glaprotein (Osteocalcin, BGP) in the blood of the patients with chronic severe hepatitis B treated by the massive plasma exchange, and to explore its mechanisms. Methods The KM8800 type liver support system was used in the treatment of 20 cases with chronic severe hepatitis B (total 36 times of treatment), 3000ml frozen plasma with same blood group being used each time. The concentrations of Ca2+, TCA, PTH and BGP in the blood of the patients before the treatments as well as just after the treatments and an hour later of the treatments were examined and compared. The same tests were also randomly taken in 10 samples of the plasma used for the exchanging purpose and in 10 samples of the blood of healthy adults, respectively. Results The concentrations of the Ca2+and TCA in the blood of the patients reduced obviously when the treatments just began compared with that before the treatments（P<0.01）, with PTH and BGP raised distinctly （P<0.01）. About an hour after the treatments, the levels of all tested indexes except BGP in serum almost return to normal. There was no distinction in the test between the blood of the patients before treatments and that of the healthy adults（P>0.05）.Ca2+ and TCA in the plasma used for exchanging decreased remarkably compared with that in blood of healthy adults（P<0.01）. Conclusion The massive plasma exchange can bring about hypocalcemia in the patients with chronic severe hepatitis B. It can be corrected by regulation of PTH and BGP in the patients themselves in short time. Such phenomena should be under monitor during and after treatments in order for the security of the therapy.