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Chinese Journal of Blood Purification ›› 2003, Vol. 2 ›› Issue (1) : 32-34.

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Abstract

【Abstract】Objective To study the therapentic effect and the satety of non-bioartifitial liver support system on severe hepatitis. Methods To treat 76 patients with severe hepatitis by way of non-bioartificial liver support system 185 times. The clinical diagnosics liver cell function, blood ammonia, plasma endotoxine, prothrombin activity and the side effecfs were observed. The contrast group consists of 63 cases of similar patients treated by the conventional therapy. Results In 76 patients with severe hepatitis ,after the treatment by non-bioartificial liver support system, the clinical symptoms were inporoved. Survival rate in the treatment group is 67.1%，31.7% in the contrast group. The levels of ALT, serum fotal bilirubin,blood ammonia, plasma endotoxine were significantly to decreased from (180.36±78.46)U/L to (79.42±64.32)U/L (P＜0.01), (310.15±90.24)umol/L to (145.26±50.76)umol/L (P ＜0.01), (119.42±65.20)ug/dl to (77.08±36.38)ug/dl (P＜0.01), prothrombin activity was significantly increased from (16±5.3)% to (32±7.2)%(P＜0.05). The incidence of adverse reaction was 36.75%. Conclusion Non-bioartificial liver support system can effectively improve the clinical symptoms and the biochemical indicators, increase the survival percentage. It is effective and safeman in severe hepatitis.