Objective To observe the effects of CRRT on patients with serve acute pancreatitis（SAP）complicated with multiple organ dysfunctions (MODS). Methods 6 patients with SAP complicated with MODS underwent CRRT in the early stage(1～3 days) besides fasting, gastrointestinal decompression, peritoneal irrigation, antibiotics, block excretion of pancreas and parenteral nutrition. Results The survival rate raise. 5 of 6 patients survived and 1 died. The survival rate was 83%. The duration and hospitalization-days shortened. 3 patients rehabilitated and discharged after 7 days and so did 2 after 13 and 21 days, respectively. The stability of cardiovascular improved. Blood pressure became stable, heart rate descented and ST depression reversed after CRRT. Hypoxia ameliorated strikingly. The SaO2 and PaO2 rised significantly after 6～24 hours of CRRT. 1 patient discontinue mechanical ventilatory support after 3 days of CRRT. The stability of interal environment was indeed assured. All patients had some types of disorder of electrolure and acid-base balance such as hyperkalemia, hyponatremia and metabolic acidosis, which were redressed after CRRT. Electrolure and acid-base balance was maintained during CRRT. Abdominalgia relieved in all patients after CRRT. Urine volume didn't reduce significantly. Half of these patients had their urine volume reduced and serum creatinine increased before CRRT, but both resumed after CRRT. The volume of infused fluid needn't be restricted during CRRT.Parenteral nutrition and other therapy could be assured. Conclusion CRRT in the early stage is an effective therapeutic option for patients with serve acute pancreatitis complicated by multiple organ dysfunctions, after which patients' condition ameliorates, duration of disease shortens and survival rate increases.