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Chinese Journal of Blood Purification ›› 2003, Vol. 2 ›› Issue (4) : 194-197.

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Abstract

Objective To Compare the anticoagulation efficiency and safety of low molecular weight heparin (LMWH) with unfractionated heparin (UFH) in hemodialysis. Methods Fourty hemodialysis patients were studied in a radomized crossover study to compare LMWH given as a single predialysis bolus injection with UFH administered with a continuous infusion, and these paitents were divided into group A and B.The data include clot formation in the dialyzer and tube,the pressure time at the puncture sife,anti-Fed levels (AFXa), activated partial thromboplastin time (APTT) and thrombin time (TT). Results the two group all finished the hemodialytic course. Compared with the UFH, there were no significant difference of the clot formation in the extracorporeal circuit and the pressure time at the puncture sites.The AFXa levels were significantly higher after hemodialysis than before in the LMWH group, and significantly higher after 30 min and at the finished time in the LMWH group than in the UFH group.There were no significant prolongat in APTT and TT levels in the LMWH group, whereas there were markedly prolongation in the UFH group, and part of hemodialysis times were uncoagulated. Conclusion The results showed that a single dose of LMWH was an effective, safe and convenient alternative to UFH.