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Chinese Journal of Blood Purification ›› 2003, Vol. 2 ›› Issue (6) : 298-300.

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Abstract

Objective To evaluate the pharmacokinetic characters of intravenous administered L-carnitine in hemodialysis patients. Methods One gram L-carnitine was given by intravenous after hemodialysis in 9 patients, blood samples were taken at 0, 1.5, 3, 15min and 0.5、1、2、4、8、12、24h to investigate the pharmacokinetic parameters for single dose L-carnitine. Then study the carnitine levels in plasma before /after hemodialysis and in hemodialysates at 0、2、4、6、8 weeks during. Results The plasma carnitine level were lower than normal in hemodialysis patients； The pharmacokinetic parameters for single dose L-carnitine were fitted two-compartment open model； L-carnitine conformed to during hemodialysis greatly；After repeated administration of L-carnitine for 6～8 weeks, the plasma carnitine level can keep stable. Conclusion The pharmacokinetic characters of intravenous administered L-carnitine in hemodialysis patients were different from normal. L-carnitine was significantly eliminated to hemodialysate, so repeated supplementations were needed for 6～8 weeks after each hemodialysis. 