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Chinese Journal of Blood Purification ›› 2003, Vol. 2 ›› Issue (6) : 319-321.

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Abstract

Objective To investigate the role of ICAM-1 in the process of peritoneum inflammation in CAPD patients and protective effects of pentoxifylline PTX.
Methods Peritoneal mesothelial cell(PMC) and macrophage were co-cultured in vitro. We observed the influence of ICAM-1 on activating PMC proliferation by macrophage and protective effect of pentoxifylline. Results The effect of activating PMC proliferation by macrophage was significantly inhibited and dosage-dependent. PTX was found to antagonize IFN-α induced adhesion reaction of PMC and macrophage. Conclusion ICAM-1 plays an important role in pathologic process of peritoneum inflammation. PTX may play an important role in peritoneal local defense and may be a protective agent which have a potential clinical value.