Abstract:

Objective To Compare the effects of short-term, high-volume hemofiltration (STHVH) therapy and intermittent hemodialysis (IHD) on severe acute pancreatitis (SAP) patients with acute renal failure (ARF). Methods Of 15 SAP patients with ARF, 9 received STHVH and 6 underwent IHD. In all cases, acute physiology indexes and 28-day survival rates were recorded. Blood urea nitrogen (BUN), serum creatinine (Scr), serum potassium, hydrocarbonic, and artery blood pH were detected in all patients every morning before hemopurification. Serum inflammatory cytokines such as tumor necrosis factor-α(TNF-α), interleukin-1β(IL-β), interleukin-8(IL-8) and anti-inflammatory cytokines interleukin-10 (IL-10) were detected in all patients before and after hemopurification. Results There was on difference of APACHE II score between two groups before the treatments (24.4±4.3 vs 23.2±3.1, P >0.05). In STHVH group APACHEⅡscore was lower than IHD group after treatment vs 20.2±2.3 (P<0.05). Daily mornning BUN, Scr, hydrocarbonic and artery blood pH had on difference between the two groups (P<0.05). Serum inflammatory cytokines TNF-α, IL-1β and IL-8 decreased in STHVH group comparing with IHD group after hemopurification. Serum IL-10 level increase term in STHVH group after therapy. Conclusion STHVH is of benift to improve the prognosis of SAP patients. 

Key words: Renal failure, Hemodialysis, Short-term high-volume hemofiltration