Abstract:

Objective To explore the changes and clinical significance of the plasmic angiotensinⅡ (AngⅡ), neuropeptide Y (NPY), neurotensin (NT) and intact parathyroid hormone (iPTH) in patients with chronic renal insufficiency.
Methods The plasmic AngⅡ、NPY and NT were measured by radioim-munoassay (RIA). The serum iPTH were measured by immunoradiometric assay (IRMA).There were four groups and twenty cases of each as group, A,B, C and D. They were normal controls, chronic renal insufficiency compensated stage, azotemia stage and uremia stage respectively. Results With the severity of renal failure,the level of AngⅡ showed an ascending tendency. Groups C and D were higher than normal control group (P<0.001); The concentration of NPY (groups B.C and D) were higher than group A (P<0.05); The level of NT showed a decending tendency, group D were lower than group A( P<0.001); The iPTH (group D) were significant higher than group A (P<0.001). In addition to the negative correlation between AngⅡ or NPY or iPTH and Ccr, the negative correlation between NT and Ccr, negative correlation between AngⅡ and NT were found. Conclusion The increased AngⅡ、NPY、iPTH and decreased NT play important roles in the further decrease of renal function and also provide theoretical bases for chronic renal failure's preventions and treatments.

Key words: Neuropeptide Y(NPY), Neurotensin(NT), Parathyroid hormone(PTH), Chronic renal insufficiency 