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Chinese Journal of Blood Purification ›› 2003, Vol. 2 ›› Issue (8) : 433-435.

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Abstract

Objective To observe the therapeutic effect and security of low molecular weight heparin(LMWH) on primary nephrotic syndrome. Methods Prednisone and other drugs were used in both control group and treatment group. LMWH(4000IU) abdomen hypodermal injection was used in treatment group. Twenty-four hour urinary protein, plasma albumin, tolal cholesterol, triglyceride, blood viscosity, thrombin time (TT), partial thromboplastin time(APTT), prothrombin time(PT), fibrinogen(FIB), platelet count were tested in both groups before and after treatment. Results The clinical symptoms relieved or disappeared in two groups after 4 weeks treatment, the effective rate in treatment group (96.6%) is significantly higher than that in control group (89.3%). The urinary protein decreased, plasma albumin elevated, tolal cholesterol, triglyceride decreased, blood viscosity decreased (P<0.05; P<0.01); treatment group excelled control group in decreasing albuminuria, elevating plasma albumin and decreasing blood viscosity (P<0.05 ; P<0.01) . After treatment the PT, TT prolonged and FIB decreased in both groups ( P<0.05; P<0.01); but the treatment group is more evident than control group. APTT prolonged and platelet decreased in two groups, but there was no significant difference between two groups. There was no hemorrhagic tendency in two groups. Conclusion LMWH treatment can improve nephrotic syndrome patient's hypercoagulability state, decrease blood viscosity, and relieve urinary protein, elevate plasma albumin. Our results showed that LMWH and enhanced the efficiency is safe.