Objective To investigate arterial elastic function of hemodialysis patients with end-stage renal disease (ESRD). Methods One hundred and seventy-two chronic hemodialysis patients with ESRD were detected before dialysis by Dynapulse200M. Results Systemic vascular compliance (SVC), brachial artery compliance (BAC) and brachial artery distensibility (BAD) of hemodialysis patients were significantly reduced in comparison to the normal standard (P<0.01). SVC, BAC and BAD of patients with pulse pressure at the level of 60～100mmHg were higher than those of patients with pulse pressure at the level of 40～60mmHg (P<0.01). Between the two groups(age≥65years and age<65years), the former had lower SVC and BAC than the latter (P<0.01), There was no significant difference of BAD (P>0.05). There was no significant change among different causes of disease and different years of hemodialysis (P>0.05). A significant correlation was found between SVC and BAD (r=0.718, P<0.01), SVC, BAC and BAD all had inverse relationship with pulse pressure, the correlation coefficient between pulse pressure and BAD was the strongest (r=0.865, P<0.01). Conclusions Arterial elastic function of hemodialysis patients with ESRD reduces prevalently, moreover, it has close relation with pulse pressure.