Objective To investigate the diagnosis and treatment of uroepithelial malignant tumor in maintenance hem dialysis patients. Methods Fourteen maintenance hemodialysis patients with uroepithelial malignant tumor from 1997 to 2002 were studied retrospectively. The primary symptom was gross hematuria with blood clot.The exact diagnosis was made by B-Ultrasound, Cystoscopy, CT and MRU examination. Results This group includes 3 cases with carcinoma of renal pelvis, 1case with carcinoma of urethra, 10 cases with bladder carcinoma. There were 7cases of bladder transitional cell carcinoma；1case of squamous cell carcinoma,1 case of adeno-squamous carcinoma, 1 case of undifferentiated carcinoma. TNM stage：T1, 2cases；T2, 3cases；T3, 5 cases. The grading in transitional cell carcinoma ：stageⅡ, 4 cases ；stage Ⅲ, 3 cases. All patients have been followed up for 8～48 months with mean 23 months, 5 of them were died. Conclusions The incidence of uroepithelial cell carcinoma was high in maintenance hemodialysis patients, and operation is the main treatment.