Objective To investigate the effects of felodipine on L-type calcium currents of rat cardiomyocytes after 5/6 subtotal nephrectomised. Method Animals were divided into three groups as follow: gorup A, 5/6 subtotal nephrectomy(SNx);group B, SNx administrated with 10mg/kg/d of felodipine; gorup C,control.Sprague-dawley rats underwent two-stage SNx; control rats underwent bilateral renal decapsulation. Animals were sacrificed after 12 weeks.Whole-cell patch clamp techniques were used to examine L-type calcium currents(ICa, L)in isolated cardiomyocytes. Results The amplitude of L-type calcium current significantly increased in SNx rats and was blocked by felodipine partly. The potential giving 50%of inactivation(V1/2) moved towards more negative in SNx rats than in control,and it had no change after administrated felodipine. Conclusions The calciumhandling of SNx rats cardiomyocytes changes.Felodipine can reverse this change of calcium handling partly and promote the voltage-dependent inactivation of L-type calcium channel.