objective To study the practical use of model for end-stage liver disease(MELD)on clinic and the role of artificial liver support system (ALSS)on end-stage liver disease. Methods Fourty-three patients were divided randomly into treatment group and control group, and they were graded with MELD before and after ALSS. The death rate was observed three months later.
Results In the treatment group,4 cases with MELD score higher than 40 before treatment of ALSS were all dead after 3 months, and 17 cases with MELD score between 30 and 40 remained a death rate of 53%;In the control group,6 cases with MELD score higher than 40 were all dead too, and the death rate of 16 cases with MELD score between 30 and 40 was 87% 3 months later; There were significant difference compared with the treatment group, (P<0.05). Conclusions MELD can be popularized in clinic and ALSS can be used safely and effectively to treat end-stage liver disease with MELD score between 30 and 40.