Objective To investigate the effect of different dialysis membranes on perepheral blood advanced oxidation protein products (AOPP) and the expression of monocyte chemokine receptor CXCR2 in maintenance hemodialysis patients(MHD). Methods The levels of perepheral blood AOPP and the expression of CXCR2 were measured by high-performance liquid chromatography and flow cytometry in the patients using dialysis membranes like cuprophone(CU)and polysulfone(PSU). Results As compared with normal control group AOPP which was (49.3±6.1) ng/mL, the levels of AOPP in MHD patients were significantly increased, but the levels of AOPP in PSU group which was (64.5±7.3) ng/mL were significantly decreased than that in CU group which is (81.7±7.1) ng/mL (P<0.01). The activity of CXCR2 was not expressed in the perepheral blood mononuclear cell of normal person, but do in the hemodialysis and non-dialysis group of uremia.CXCR2 activity was lower in the non-dialysis group, while was higher in the dialysis group,which in CU group was significantly increased than that in PSU group( P<0.05). There is a positive correlation between AOPP levels and CXCR2 expression in CU group and PSU group. Conclusion Hemodialysis could activate the cellular environment into oxidative stress condition through the reaction between blood and dialysis membrane,and could induce perepheral blood mononuclear cells to synthesize more AOPP, while abnormally increased AOPP would increase the expression of chemokine receptor CXCR2 on monocyte; But different dialysis membranes, such as CU and PSU, would have different effects on AOPP and CXCR2 in the MHD patients.All of these changes are associated with the dialysis membrane's biocompatibility.