Objectives To investigate the effect of homocysteine (HCY) on mPGEs. Expression of human peripheral blood mononuclear cell. Methods PBMC isolated from healthy volunteers, were cultured and intervened with HCY, Troglitazone and Rosiglitazone for 24 hours. mPGEs expression in the supernatants of cell culture were analyzed by ELISA. Results The OD value of mPGEs in HCY experimental groups were higher than in controls (P<0.05). The OD value of mPGEs increased with a HCY dosage-dependent style between 20μmol/L to 100μmol/L. All groups of Troglitazone and Rosiglita-zone significantly reduced the level of mPGEs induced by 100μmol/L HCY (P<0.01), but there was no significant difference between the two PPAR-P activator groups (P>0.05). Conclusions HCY could stimulate PBMC to express mPGEs dosage-dependently. PPAR-γactivators could inhibit PBMC releasing and expressing mPGEs induced by HCY. 