Objective To explore an effective scheme to rescue acute tetramine poisoning. Methods Fourty-four cases were randomly divided into two groups the control group (n=24) and the test group (n=20). The patients in control group were given HP and routine therapy. The patients in the test group were given Na-DMPs, HP and routine therapy. The duration of twitch, coma and respiratory failure, CK, CKMB, ALT and Cr were observed and compared between the two groups. Results The twitch, coma, respiratory failure duration of the test group was shorter than the control`s［(2.1±0.7)d vs (3.7±2.2)d, (28.7±4.6)h vs (33.5±10.1)h, (2.1±0.8)d vs (4.3±1.1)d respectively P<0.05)］. CK and Cr were significantly lower than the control`s. CK and Cr had positive correlation with the twitch (r=0.863,0.727, P<0.05). Conclusions The treatment of acute tetramine poisoning with Na-DMPs accompanied by HP was better than only HP. It can control the twitch rapidly, shorten the coma duration, then alleviate the injury of heart, liver, brain and kidney.