Objectives Under the condition of constant ultrafiltration volume, to observe the influence of different ultrafiltration rate or it combining with sodium modeling hemodialysis on the frequency of hypotension. Methods Thirty-two patients were divided into the old aged group and the younger aged group. According to the frequency of hypotension during hemodialysis sessions, their regular HD results and HD results after adjusting ultrafiltration rate or it combining with sodium modeling hemodialysis were studied and compared. Result The frequency of hypotension during dialysis was significantly higher in the old aged group compared with that in the younger aged group. Adjusting ultrafiltration rate or it combining with sodium modeling hemodialysis could make the frequency of hypotension became lower. Conclusions The UFV during hemodialysis was a key factor in the occurrence of hypotension. After the proper UFV was determined, the ultrafiltration rate or it combining with sodium modeling hemodialysis were main factors influencing the frequency of hypotension.