Objective The serum albumin concentration is an important index to evaluate the nutritional status of the chronic renal failure patients. It is important to understand the relationship between standard deviation of Kt/V（σKt/V）and the serum albumin concentration of chronic maintenance hemodialysis patients, which may help to observe the role of σKt/V in evaluating the hemodialysis quality of the chronic hemodialysis patients. Methods 74 chronic maintenance hemodialysis patients had been investigated. Choose five sessions hemodialysis randomly, measured the serum albumin concentration before hemodialysis, calculated the σKt/V of each patient, analyzed the correlation between σKt/V and the serum albumin concentration.Results We found that there was a significant negative correlation between the σKt/V and the serum albumin concentration in chronic maintenance hemodialysis patients. Conclusions The basic ststus of maintenance hemodialysis patients was closely correlated to the serum albumin concentration. For the chronic maintenance hemodialysis patients, the serum albumin concentration is one of the important matter used to evaluate the basic status of the patients and the effect of the hemodialysis therapy. The σKt/V range of the chronic maintenance hemodialysis patients is an valuable parameter to reflect the quality of hemodialysis therapy. σKt/V is an important indication to evaluate the general clinic condition of the chronic maintenance hemodialysis patients.