Objective To discuss the effect of different dialysisi methods on treating acute renal failure complicated by cerebral trauma. Methods The 43 patients we rerandomly divided into three groups: HF group(14 cases),PD group(13 cases) and CRRT (16 cases)group. Results The mortality rate in HF group was 71.4%, which was statisticly higher than the rate in PD(30.8%) and CRRT(25.0%) group, P<0.05. The bleeding rate related with dialysis was 56.3% in CRRT group, 28.6% in HF group, and 7.7% in PD group, there was a statistical difference among the three groups. The changes of cerebral fluid pressure and the plasma osmotic pressure in HF group was statisticly different from the change in PD and CRRT group. The infectious rate related with dialysis had no difference among the three groups. Conclusion The treatment of acute renal failure complicated by cerebral trauma with PD and CRRT were better than HF, but the bleeding and infection should be pay attention to, early treatment can improve the surviral rate.